Assessment of metabolic bone diseases by quantitative computed tomography

Journal Article · Wed May 01 04:00:00 EDT 1985 · Clin. Orthop. Relat. Res.; (United States)

DOI:https://doi.org/10.1097/00003086-198505000-00026· OSTI ID:5519540

Richardson, M L; Genant, H K; Cann, C E; Ettinger, B; Gordan, G S; Kolb, F O; Reiser, U J

Advances in the radiologic sciences have permitted the development of numerous noninvasive techniques for measuring the mineral content of bone, with varying degrees of precision, accuracy, and sensitivity. The techniques of standard radiography, radiogrammetry, photodensitometry, Compton scattering, neutron activation analysis, single and dual photon absorptiometry, and quantitative computed tomography (QCT) are described and reviewed in depth. Results from previous cross-sectional and longitudinal QCT investigations are given. They then describe a current investigation in which they studied 269 subjects, including 173 normal women, 34 patients with hyperparathyroidism, 24 patients with steroid- induced osteoporosis, and 38 men with idiopathic osteoporosis. Spinal quantitative computed tomography, radiogrammetry, and single photon absorptiometry were performed, and a spinal fracture index was calculated on all patients. The authors found a disproportionate loss of spinal trabecular mineral compared to appendicular mineral in the men with idiopathic osteoporosis and the patients with steroid-induced osteoporosis. They observed roughly equivalent mineral loss in both the appendicular and axial regions in the hyperparathyroid patients. The appendicular cortical measurements correlated moderately well with each other but less well with spinal trabecular QCT. The spinal fracture index correlated well with QCT and less well with the appendicular measurements.

• Research Organization: Univ. of California School of Medicine, San Francisco
• OSTI ID: 5519540
• Journal Information: Clin. Orthop. Relat. Res.; (United States), Journal Name: Clin. Orthop. Relat. Res.; (United States) Vol. 195; ISSN CORTB
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ACTIVATION ANALYSIS
BARYON REACTIONS
BIOMEDICAL RADIOGRAPHY
BODY
CHEMICAL ANALYSIS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
HADRON REACTIONS
HYPERPARATHYROIDISM
MEASURING METHODS
MEDICINE
METABOLIC DISEASES
MINERALS
NEUTRON REACTIONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANS
OSTEOPOROSIS
PATIENTS
RADIOLOGY
SKELETAL DISEASES
SKELETON
TOMOGRAPHY