Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-97-5-699· OSTI ID:6256160

Genant, H K; Cann, C E; Ettinger, B; Gordan, G S

The bone mineral loss was assessed serially in 37 premenopausal women for 24 months after oophorectomy and the dose-response for conjugated estrogen therapy in preventing this loss was determined. Spinal cancellous bone was measured by quantitative computed tomography and measurement of appendicular cortical bone by radial photon absorptiometry and metacarpal radiogrammetry. For the placebo and low-dose treatment groups, the mean annual bone mineral losses were 7% to 9% from the vertebral spongiosum and 1% to 3% from the peripheral cortex. The correlation between axial and appendicular loss was weak, precluding a reliable estimate of spinal loss from peripheral measurements. For the maximal-dose group (0.6 mg/d), the mean annual bone mineral losses were less than 0.5% from the axial and appendicular sites, and were not significant. The results indicate that spinal quantitative computed tomography provides a highly sensitive measurement of bone mineral loss after oophorectomy, that bone mineral loss is five- to sevenfold greater from the spinal spongiosum than from the appendicular cortex, and that conjugated estrogen in doses of less than 0.6 mg/d are inadequate to prevent the vertebral mineral loss.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6256160
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 97:5; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ESTROGENS
FEMALE GENITALS
FEMALES
GONADS
HORMONES
MAMMALS
MAN
MEDICINE
MOCKUP
ORGANS
OSTEOPOROSIS
OVARIES
PATIENTS
PHANTOMS
PRIMATES
SENSITIVITY
SKELETAL DISEASES
SKELETON
STEROID HORMONES
STRUCTURAL MODELS
SURGERY
TOMOGRAPHY
VERTEBRAE
VERTEBRATES
WOMEN