Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Journal of Clinical Endocrinology and Metabolism; (USA)

DOI:https://doi.org/10.1210/jcem-69-4-776· OSTI ID:5361939

Finkelstein, J S; Klibanski, A; Neer, R M; Doppelt, S H; Rosenthal, D I; Segre, G V; Crowley, Jr, W F ^[1]

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1. Massachusetts General Hospital, Boston (USA)

To assess the effects of gonadal steroid replacement on bone density in men with osteoporosis due to severe hypogonadism, we measured cortical bone density in the distal radius by 125I photon absorptiometry and trabecular bone density in the lumbar spine by quantitative computed tomography in 21 men with isolated GnRH deficiency while serum testosterone levels were maintained in the normal adult male range for 12-31 months (mean +/- SE, 23.7 +/- 1.1). In men who initially had fused epiphyses (n = 15), cortical bone density increased from 0.71 +/- 0.02 to 0.74 +/- 0.01 g/cm2 (P less than 0.01), while trabecular bone density did not change (116 +/- 9 compared with 119 +/- 7 mg/cm3). In men who initially had open epiphyses (n = 6), cortical bone density increased from 0.62 +/- 0.01 to 0.70 +/- 0.03 g/cm2 (P less than 0.01), while trabecular bone density increased from 96 +/- 13 to 109 +/- 12 mg/cm3 (P less than 0.01). Cortical bone density increased 0.03 +/- 0.01 g/cm2 in men with fused epiphyses and 0.08 +/- 0.02 g/cm2 in men with open epiphyses (P less than 0.05). Despite these increases, neither cortical nor trabecular bone density returned to normal levels. Histomorphometric analyses of iliac crest bone biopsies demonstrated that most of the men had low turnover osteoporosis, although some men had normal to high turnover osteoporosis. We conclude that bone density increases during gonadal steroid replacement of GnRH-deficient men, particularly in men who are skeletally immature.

• OSTI ID: 5361939
• Journal Information: Journal of Clinical Endocrinology and Metabolism; (USA), Journal Name: Journal of Clinical Endocrinology and Metabolism; (USA) Vol. 69:4; ISSN JCEMA; ISSN 0021-972X
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE PHOSPHATASE
ANDROGENS
ANDROSTANES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DENSITY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
KETONES
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OSTEOPOROSIS
PHOSPHATASES
PHOTON EMISSION SCANNING
PHYSICAL PROPERTIES
PRIMATES
PROCESSING
RADIOISOTOPES
SKELETAL DISEASES
SKELETON
STEROID HORMONES
STEROIDS
TESTOSTERONE
TOMOGRAPHY
VERTEBRATES