Excretion and retention of cadmium, zinc, and mercury by rabbit kidney

Journal Article · Sun Dec 01 00:00:00 EST 1974 · Am. J. Physiol.; (United States)

OSTI ID:5517865

Foulkes, E C

Mean renal artery-to-vein transit times (anti t) of /sup 109/Cd, /sup 65/Zn, or /sup 203/Hg were compared to those of Evans blue (EB) and inulin in rabbits. All three elements were fully recovered in venous plasma, where they slightly preceded inulin, although anti t exceeded anti t/sub EB/. Competition for the injected metals is suggested between circulating plasma protein and fixed endothelial ligands. Upon addition of mercaptoethanol (ME) to the bolus injection, /sup 109/Cd appeared in urine; total recovery in blood and urine dropped to two-thirds of the dose reaching the kidney. Renal retention of the remaining one-third was reduced by 30% after ureteral occlusion. Both luminal and peritubular cell membranes thus are involved in Cd uptake, a conclusion in agreement with the previous finding of lesions at those two sites. In the presence of ME, essentially all /sup 203/Hg was retained in the kidney but renal handling of Zn was not affected. The stronger chelator EDTA led to recoveries of /sup 109/Cd in blood and urine approaching those of inulin. These results bear on the role of metal ligands in determining renal excretion and accumulation of heavy metals. 17 references, 2 figures, 4 tables.

• Research Organization: Univ. of Cincinnati College of Medicine, OH
• OSTI ID: 5517865
• Journal Information: Am. J. Physiol.; (United States), Vol. 227:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM 109
RENAL CLEARANCE
RETENTION
KIDNEYS
RADIONUCLIDE KINETICS
MERCURY 203
ZINC 65
BLOOD
CELL MEMBRANES
COMPARATIVE EVALUATIONS
EDTA
EVANS BLUE
INULIN
LIGANDS
PROTEINS
RABBITS
URINE
AMINO ACIDS
ANIMALS
AZO COMPOUNDS
AZO DYES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CADMIUM ISOTOPES
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DYES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MATERIALS
MEMBRANES
MERCURY ISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
REAGENTS
SACCHARIDES
SULFONIC ACIDS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
ZINC ISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques