Excretion and retention of cadmium, zinc, and mercury by rabbit kidney

Journal Article · Sun Dec 01 04:00:00 EST 1974 · Am. J. Physiol.; (United States)

OSTI ID:5517865

Foulkes, E C

Mean renal artery-to-vein transit times (anti t) of /sup 109/Cd, /sup 65/Zn, or /sup 203/Hg were compared to those of Evans blue (EB) and inulin in rabbits. All three elements were fully recovered in venous plasma, where they slightly preceded inulin, although anti t exceeded anti t/sub EB/. Competition for the injected metals is suggested between circulating plasma protein and fixed endothelial ligands. Upon addition of mercaptoethanol (ME) to the bolus injection, /sup 109/Cd appeared in urine; total recovery in blood and urine dropped to two-thirds of the dose reaching the kidney. Renal retention of the remaining one-third was reduced by 30% after ureteral occlusion. Both luminal and peritubular cell membranes thus are involved in Cd uptake, a conclusion in agreement with the previous finding of lesions at those two sites. In the presence of ME, essentially all /sup 203/Hg was retained in the kidney but renal handling of Zn was not affected. The stronger chelator EDTA led to recoveries of /sup 109/Cd in blood and urine approaching those of inulin. These results bear on the role of metal ligands in determining renal excretion and accumulation of heavy metals. 17 references, 2 figures, 4 tables.

• Research Organization: Univ. of Cincinnati College of Medicine, OH
• OSTI ID: 5517865
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 227:6; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AZO COMPOUNDS
AZO DYES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CADMIUM 109
CADMIUM ISOTOPES
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHELATING AGENTS
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DYES
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EVANS BLUE
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
INULIN
ISOTOPES
KIDNEYS
LIGANDS
MAMMALS
MATERIALS
MEMBRANES
MERCURY 203
MERCURY ISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
POLYSACCHARIDES
PROTEINS
RABBITS
RADIOISOTOPES
RADIONUCLIDE KINETICS
REAGENTS
RENAL CLEARANCE
RETENTION
SACCHARIDES
SULFONIC ACIDS
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
ZINC 65
ZINC ISOTOPES