Renal tubular handling of /sup 203/Hg/sup 2 +/ in the dog: a microinjection study

Journal Article · Tue Apr 01 04:00:00 EST 1980 · Environ. Res.; (United States)

OSTI ID:5024199

Cikrt, M; Heller, J

/sup 203/HgCl/sub 2/ in trace amounts was injected together with (methoxy-/sup 3/H)inulin into the proximal convoluted tubules of the dog kidney superficial nephrons. Of the injected inulin, 97.3 +- 5.7% was recovered in the urine from the injected kidney. From the injected /sup 203/Hg only 8.2 +- 1.0% was recovered in the urine from the injected kidney and 0.4 +- 0.7% from the contralateral kidney. These results were not significantly influenced by intrarterial infusion of KCN, ouabain, or 2,4-dinitrophenol, indicating that there occurred no active tubular reabsorption of mercury. Of the injected /sup 203/Hg, 88.2 to 93.5% was recovered in the kidney whose tubules were punctured. When /sup 203/Hg was injected into peritubular capillary, only 1.2 +- 0.7% was recovered in the urine from the injected and 0.91 +- 0.2% from the contralateral kidney, this difference being not significant. Results are interpreted as lacking evidence for active transport mechanism of Hg/sup 2 +/ in the dog kidney under conditions of microinjection experiment.

• Research Organization: Inst. of Hygiene and Epidemiology, Prague, Czechoslovakia
• OSTI ID: 5024199
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 21:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOHYDRATES
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DOGS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HYDROGEN ISOTOPES
INJECTION
INTAKE
INULIN
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MATERIALS
MERCURY 203
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
MERCURY ISOTOPES
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS
SACCHARIDES
TRACER TECHNIQUES
TRITIUM
TUBULES
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES