Toxicokinetics and disposition of mercuric and cadmium chloride in channel catfish after intravascular administration
Conference
·
OSTI ID:230870
- Savannah River Ecology Lab., Aiken, SC (United States)
To better understand the distribution and elimination of inorganic mercury and cadmium in fish, {sup 203}HgCl{sub 2} and {sup 109}CdCl{sub 2} were administered to channel catfish (Ictalurus punctatus) via an intra-aortic cannula. Blood was serially removed from individual fish for at least 158 days after injection and the concentrations of {sup 203}Hg and {sup 109}Cd in whole blood, plasma and red blood cells (RBC) were determined. Additionally, the amount of {sup 203}Hg and {sup 109}Cd in the whole animal was serially determined by whole-body counting of the lightly anesthetized fish with a gamma spectroscopy system. Initially, the concentrations of {sup 203}Hg and {sup 109}Cd in blood and plasma declined rapidly and then slowly decreased with detectable amounts still present after 158 days. By 300 hrs post-injection, the majority of the {sup 203}Hg and {sup 109}Cd in the blood was associated with the RBC. The amount of {sup 203}Hg in the whole animal declined slowly with < 50% of the injected dose excreted after 158 days. {sup 109}Cd was eliminated very slowly with < 15% of the dose excreted after 230 days. The majority of {sup 203}Hg and {sup 109}Cd was associated with the liver, trunk and head kidneys. The {sup 203}Hg and {sup 109}Cd concentration time curves in plasma, RBC`s and the amount in the whole animal were fitted simultaneously to a 4 compartment toxicokinetic model to obtain estimates of the apparent volume of distribution and total body clearance.
- OSTI ID:
- 230870
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Methyl mercury toxicokinetics in channel catfish (Ictalurus punctatus) and largemouth bass (Micropterus salmoides) after intravascular administration
Metabolism of Mercurascan-$sup 203$Hg by rats and dogs
Excretion and retention of cadmium, zinc, and mercury by rabbit kidney
Journal Article
·
Thu May 01 00:00:00 EDT 1997
· Environmental Toxicology and Chemistry
·
OSTI ID:514538
Metabolism of Mercurascan-$sup 203$Hg by rats and dogs
Journal Article
·
Sun Dec 31 23:00:00 EST 1972
· J. Nucl. Biol. Med., v. 17, no. 2, pp. 43-50
·
OSTI ID:4406736
Excretion and retention of cadmium, zinc, and mercury by rabbit kidney
Journal Article
·
Sat Nov 30 23:00:00 EST 1974
· Am. J. Physiol.; (United States)
·
OSTI ID:5517865