Practical SPECT technique for quantitation of drug delivery to human tumors and organ absorbed radiation dose

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Seminars in Nuclear Medicine; (USA)

DOI:https://doi.org/10.1016/S0001-2998(89)80034-0· OSTI ID:5515637

Iosilevsky, G; Israel, O; Frenkel, A; Even-Sapir, E; Ben-Haim, S; Front, A; Kolodny, G M; Front, D ^[1]

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1. Rambam Medical Center, Haifa (Israel)

A practical quantitative single photon emission computed tomographic (SPECT) technique based on an empirical threshold analysis permits accurate measurements in humans of drug delivery and absorbed radiation dose. The limits of the method have been explored using a wide range of phantom volumes, concentrations, and target-to-nontarget ratios. A threshold of 43% was found to give the best results using volumes of 30 to 3,800 cc. An excellent correlation (r = .99 with a standard error of estimate (SEE) of 41 cc) was found between SPECT measured volumes and actual phantom volumes. A similarly high correlation (r = .98, SEE = 260 counts/voxel) was found in 77 measurements of concentrations between 0.01 and 3.6 microCi/cc. There was a direct relationship between the target-to-nontarget ratio of phantoms and the accuracy of volume measurements. The technique has been validated by an excellent in vivo/in vitro correlation of uptake in human tumors. The tumor cumulative concentration and tumor-to-blood ratio were used for assessment of drug delivery. In vivo quantitative measurements of the pharmacokinetics of technetium-99m (99mTc) glucoheptonate, cobalt-57 (57Co) bleomycin and platinum-195m (195mPt) cisplatin in human tumors in vivo indicates that, in contrast with tumor models in animals, there is a marked variability in drug delivery even in tumors with the same histology. Future development of labeled drugs should make it possible to use quantitative SPECT for predicting tumor response to therapy and for tailoring chemotherapy for the individual patient under treatment. SPECT quantitation of organ concentration was used for Medical Internal Radiation Dose committee (MIRD) calculations of organ absorbed radiation dose from 99mTc-labeled RBCs. 48 references.

• OSTI ID: 5515637
• Journal Information: Seminars in Nuclear Medicine; (USA), Journal Name: Seminars in Nuclear Medicine; (USA) Vol. 19:1; ISSN 0001-2998; ISSN SMNMA
• Country of Publication: United States
• Language: English

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ACCURACY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COBALT 57
COBALT ISOTOPES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOCUMENT TYPES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ERYTHROCYTES
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MATERIALS
MOCKUP
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHANTOMS
PLATINUM 195
PLATINUM ISOTOPES
PRIMATES
RADIATION DOSES
RADIOISOTOPES
REVIEWS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STABLE ISOTOPES
STRUCTURAL MODELS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTING
TISSUE DISTRIBUTION
TOMOGRAPHY
VALIDATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES