SPECT quantitation of iodine-131 concentration in phantoms and human tumors

Journal Article · Sat Dec 01 04:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6212169

Israel, O; Iosilevsky, G; Front, D; Bettman, L; Frenkel, A; Ish-Shalom, S; Steiner, M; Ben-Harush, M; Kolodny, G M ^[1]

---

1. Rambam Medical Center, Haifa (Israel)

The validity of SPECT measurement of iodine-131 ({sup 131}I) concentration was tested in vitro in phantoms and in vivo by measuring bladder urine concentrations. Phantom studies comparing known and SPECT measured concentrations showed a good correlation for {sup 131}I (r = 0.98, s.e.e. = 20.94 counts/voxel) for phantoms of 25 to 127 cc and concentrations of 0.13 to 9.5 microCi/cc. The in vivo, in vitro correlation of {sup 131}I concentrations in the urine was also good (r = 0.98, s.e.e. = 0.677 microCi/cc). Quantitative SPECT was used to calculate the effective half-life and dosimetry of radioiodine in 12 sites of thyroid carcinoma in seven patients. SPECT was also used to determine the dosimetry of ({sup 131}I)MIBG (metaiodobenzylguanidine) in two patients with carcinoid, two with neuroblastoma, and one with pheochromocytoma. The radiation dose for thyroid carcinoma metastases varied between 6.3 and 276.9 rad/mCi. The dose from MIBG varied between 13.4 and 57.8 rad/mCi. These results indicate the validity of quantitative SPECT for in vivo measurement of {sup 131}I and the need to measure the concentration of {sup 131}I in individual human tumor sites.

• OSTI ID: 6212169
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:12; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
655003 -- Medical Physics-- Dosimetry
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSIMETRY
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
GLANDS
IN VIVO
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MAMMALS
MAN
MATERIALS
MOCKUP
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHANTOMS
PRIMATES
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STRUCTURAL MODELS
TESTING
THYROID
TOMOGRAPHY
URINE
VALIDATION
VERTEBRATES
WASTES