In vivo quantitation using SPECT of radiopharmaceutical uptake by human meningiomas

Journal Article · Wed Jul 01 04:00:00 EDT 1987 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.164.1.3035609· OSTI ID:6476323

Front, D; Ioselevsky, G; Frenkel, A; Even-Sapir, E; Israel, O; Kolodny, G M; Feinsud, M

A single photon emission computed tomographic method was designed for the measurement of radiopharmaceutical uptake in brain tumors. Results of phantom studies showed a correlation coefficient of .99 when measured volume was compared with actual volume. The correlation coefficient for measured radioactivity concentration compared with the actual concentration was .97. In 13 meningiomas the correlation between in vivo SPECT measurements of uptake and in vitro measurements in samples of the same tumors removed surgically was .84; when two tumors that contained regions of necrosis and fibrosis were excluded it was .93. This method can be used for in vivo quantitative assessment of pharmacokinetics of labeled drug uptake in human brain tumors.

• Research Organization: Israel Institute of Technology, Haifa
• OSTI ID: 6476323
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
LABELLED COMPOUNDS
MAMMALS
MAN
MOCKUP
NEOPLASMS
NERVOUS SYSTEM
ORGANS
PHANTOMS
PRIMATES
RADIOPHARMACEUTICALS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STRUCTURAL MODELS
TOMOGRAPHY
UPTAKE
VERTEBRATES