Human fibroblast strain with normal survival but abnormal postreplication repair after ultraviolet light irradiation
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:5512211
Postreplication repair has been studied in ultraviolet light (UV-irradiated) fibroblast strains derived from eight apparently normal control donors and seven xeroderma pigmentosum patients. One control donor strain had an intermediate defect in postreplication repair similar to that in excision-deficient xeroderma pigmentosum fibroblasts. However, unlike the xeroderma pigmentosum strains, this control donor strain had normal UV-induced unscheduled DNA synthesis and normal survival after irradiation with UV. This unique fibroblast strain should be useful in studies designed to elucidate the possible role of postreplication repair in UV-induced carcinogenesis and mutagenesis.
- Research Organization:
- National Cancer Inst., Bethesda, MD
- OSTI ID:
- 5512211
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 40:8; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Human subject with a new defect in repair of ultraviolet damage. [Ultraviolet radiation]
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· Proc. Natl. Acad. Sci. U.S.A.; (United States)
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONNECTIVE TISSUE CELLS
DISEASES
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FIBROBLASTS
INJURIES
IRRADIATION
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONNECTIVE TISSUE CELLS
DISEASES
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FIBROBLASTS
INJURIES
IRRADIATION
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM