Human subject with a new defect in repair of ultraviolet damage. [Ultraviolet radiation]
Journal Article
·
· J. Invest. Dermatol.; (United States)
The subject under study (11961) is a child with extreme sun sensitivity. Fibroblasts derived from the child's skin, like those from patients with the disorder xeroderma pigmentosum were hypersensitive to the lethal effects of 254 nm and 310 nm uv-irradiation. Unlike xeroderma pigmentosum cells, however, fibroblasts from our subject were not hypersensitive to the chemical mutagen N-hydroxyacetylaminofluorene but they were hypersensitive to ethylmethanesulfonate. Furthermore, despite the ultraviolet light sensitivity, no defects could be detected either in excision or postreplication repair of damaged DNA after uv-irradiation of 11961 cells. This again contrasts with xeroderma pigmentosum cells, which are defective in one or the other of these repair processes. On the basis of these characteristics and the clinical symptoms, we are not at present able to classify this patient as having any of the known sun-sensitive syndromes.
- Research Organization:
- Univ. of Sussex, Brighton, England
- OSTI ID:
- 5760126
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 70:4; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
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COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
MAMMALS
MAN
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PRIMATES
RADIATIONS
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RECOVERY
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SKIN
SKIN DISEASES
SOMATIC CELLS
ULTRAVIOLET RADIATION
VERTEBRATES
XP CELLS