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Comparison of two nitroimidazoles and a dihydroquinoline as radiosensitizers and cytotoxic agents

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5512155
 [1]; ; ; ;
  1. Columbia Univ., NY
+ Show Author Affiliations
The search for electron affinic compounds that exhibit the properties needed for a clinically useful hypoxic cell radiosensitizer has led to the setting up of clinical trials with misonidazole, which is a 2-nitroimidazole. Recently, MTDQ a new drug of novel design, a dihydroquinoline (6,6-methylene-bis-2,2,4-trimethyl-1,2-dihydroquinoline) has been synthesized and suggested as a radiosensitizer. The radiosensitizing and cytotoxic properties of misonidazole are compared with MTDQ and a second 2-nitroimadazole Ro-07-0741, which has warranted attention as a possible alternative to misonidazole for clinical use.
DOE Contract Number:
EP-78-S-02-4733
OSTI ID:
5512155
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:10
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
HAMSTERS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEUTRON CAPTURE THERAPY
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
THERAPY
TIME DEPENDENCE
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES