Investigation of radiosensitivity of human bone marrow cells that form colonies in agar cultures

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5512094

Zherbin, E A; Kolesnikova, A I; Konoplyannikov, A G; Khoptynskaya, S K

Heretofore, the radiosensitivity of cells of human hemopoietic organs was investigated primarily by indirect methods, according to changes in cellularity of tissue, yield of chromosmal aberrations, and inhibition of mitotic activity. With development of the method of cultivation of partially committed stem cells in semiliquid agar, it became possible to make quantitative studies of their radiosensitivity. However, few data have been accumulated thus far on this subject. Also unclear is the question of how various diseases in the bone marrow donor, without changes in the blood system, could affect radiosensitivity of cells of the stem type, since the easiest way of obtaining material is during resections of flat bones and bone marrow punctures performed for therapeutic and diagnostic purposes on various patients. The results of a study of the curves of dose-survival of colony forming units (CFU), that produce colonies in cultures on semiliquid agar (CFU/sub c/), contained in the bone marrow of five patients with various diseases without any changes in the blood system are reported.

• Research Organization: Scientific Research Inst. of Medical Radiology, Obninsk, USSR
• OSTI ID: 5512094
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:4; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BONE MARROW CELLS
CELL CULTURES
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EMPHYSEMA
GAMMA RADIATION
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
OSTEOSARCOMAS
RADIATION DOSES
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM DISEASES
SARCOMAS
SKELETAL DISEASES
SOMATIC CELLS
SURVIVAL CURVES
TUBERCULOSIS
YEARS LIVING RADIOISOTOPES