Granulocytopoietic precursor cells and regulatory factors in irradiated human bone marrow
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The effects of irradiation on committed granulopoietic progenitor cells (CFU-C) and granulopoietic humoral regulators were studied in 17 X-ray treated patients with carcinoma of the breast or of the prostate. After 45 or 70 Gy, the CFU-C decreased to 14 +/- 10% in irradiated areas. The frequency of peripheral blood CFU-C did not change after irradiation. Endogenous colony stimulating activity (CSA), i.e., release of CSA within the marrow cell population, in post-irradiation bone marrow persisted on roughly the same level, indicating a fairly low radiosensitivity of the CSA-producing cells in the bone marrow. Colony stimulating activity in peripheral blood cells and serum remained unchanged, but there were great interindividual variations, and some of the patients with hypercellularity and CFU-C increase in nonirradiated marrow areas also had increased CSA. Serum lipoprotein inhibitors were higher in the post-treatment patients than in health control patients.
- Research Organization:
- Sundsvalls Hospital, Sweden
- OSTI ID:
- 5302225
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
BONE MARROW CELLS
CARCINOMAS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
GLANDS
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LEUKOCYTES
LEUKOPOIESIS
LIPIDS
LIPOPROTEINS
MALE GENITALS
MAMMARY GLANDS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROSTATE
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
TISSUES
X RADIATION
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
BONE MARROW CELLS
CARCINOMAS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
GLANDS
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LEUKOCYTES
LEUKOPOIESIS
LIPIDS
LIPOPROTEINS
MALE GENITALS
MAMMARY GLANDS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROSTATE
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
TISSUES
X RADIATION