Analysis of age-related radiosensitivity of mice. [x rays]

Journal Article · Mon Oct 01 04:00:00 EDT 1979 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5463700

Bogatyrev, A V; Timoshenko, S I; Nikanorova, N G; Sverdlov, A G

To determine the mechanisms of age-related differences in radiosensitivity of mice, a study was made of sensitivity of bone marrow stem cells from animals of different ages exposed to radiation in vitro, postradiation restoration of peripheral blood leukocyte level and cellularity of bone marrow and spleen. It was demonstrated by the method of spleen colonies that there is the same vulnerability of bone marrow cells in mice of all age groups. The level of restoration of the pool of hemopoietic cells is considerably lower in neonate mice than in adult ones exposed to radiation in equally effective doses (LD/sub 50/ /sub 30/).

• Research Organization: Institute of Nuclear Physics, Leningrad, USSR
• OSTI ID: 5463700
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:2; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE DEPENDENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW CELLS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
IN VITRO
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
LEUKOCYTES
MAMMALS
MATERIALS
MICE
NEONATES
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
SPLEEN COLONY FORMATION
STEM CELLS
TISSUE CULTURES
VERTEBRATES
X RADIATION