Microdistribution of Thorotrast conglomerates in lymph nodes and radiation exposure of single lymphocytes

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(79)90133-6· OSTI ID:5511352

Steinstraesser, A; Kemmer, W; Muth, H

In Thorotrast patients, chromosome aberrations of lymphocytes from peripheral blood are to be used as a biological dosimeter. To get a significant dose-effect relationship it is necessary to estimate the absorbed dose of a single lymphocyte during its exposure time. In individual cases only average values can be calculated, based on assumptions of special distributions of Thorotrast. At first effects of the size of Thorotrast conglomerates and of their space distribution on the ..cap alpha..-radiation dose distribution in their surroundings are described in a model. Then this model is transferred to the real dimensions and the histological structures of lymph nodes bearing Thorotrast. In some individual cases the microdistribution of Thorotrast has been determined in lymph nodes. Some of these results are demonstrated. According to these Thorotrast distributions, calculation of real absorbed dose of lymphocytes are performed. These values can be used for setting up a dose-effect relationship for biological dosimetry.

• Research Organization: Universitaet des Saarlandes, Homburg, Germany
• OSTI ID: 5511352
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 18:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

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560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
AGGLOMERATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHALCOGENIDES
CHROMOSOMAL ABERRATIONS
COLLOIDS
CONNECTIVE TISSUE CELLS
CONTRAST MEDIA
DATA
DATA FORMS
DISPERSIONS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
HAMSTERS
INFORMATION
ISOLATED VALUES
LEUKOCYTES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MUTATIONS
NUMERICAL DATA
OXIDES
OXYGEN COMPOUNDS
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIOCOLLOIDS
RADIOINDUCTION
RADIONUCLIDE KINETICS
RODENTS
SOMATIC CELLS
THORIUM COMPOUNDS
THORIUM OXIDES
THOROTRAST
VERTEBRATES