Population and pedigree studies reveal a lack of association between the dopamine D sub 2 receptor gene and alcoholism

Journal Article · Wed Dec 26 00:00:00 EST 1990 · JAMA, Journal of the American Medical Association; (United States)

DOI:https://doi.org/10.1001/jama.1990.03450240058040· OSTI ID:5509534

Bolos, A M; Goldman, D; Brown, G L ^[1]; Lucas-Derse, S; Ramsburg, M ^[2]

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1. National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (USA)
2. Program Resources Inc., Frederick, MD (USA)

Using the dopamine D{sub 2} receptor clone {lambda}hD2G1, Blum et al recently found that the D{sub 2}/Taq 1 allele (A1) was present in 69{percent} of 35 deceased alcoholics but in only 20{percent} of an equal number of controls. To assess this association further, the authors evaluated the D{sub 2}/Taq 1 polymorphism and a single-strand conformation polymorphism detected by polymerase chain reaction and nondenaturing gel electrophoresis (PCR-SSCP) of the 3{prime} noncoding region of the D{sub 2} receptor gene. They studied 40 unrelated white alcoholics, 127 racially matched controls, and two white pedigrees. The Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L) clinical diagnostic interviews were rated blindly by two clinicians. Alcoholics were subtyped according to age of onset, severity, presence of antisocial personality, and family history. No significant differences in either D{sub 2}/Taq 1 or PCR-SSCP allele frequencies were observed between alcoholics, subpopulations of alcoholics, or controls. The PCR-SSCP polymorphism provided independent information against linkage at the D{sub 2} receptor locus. This study does not support a widespread or consistent association between the D{sub 2} receptor gene and alcoholism.

• OSTI ID: 5509534
• Journal Information: JAMA, Journal of the American Medical Association; (United States), Vol. 264:24; ISSN 0098-7484
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
RECEPTORS
METABOLIC DISEASES
PATHOLOGY
DIAGNOSIS
DNA POLYMERASES
GENOTYPE
PATIENTS
RFLPS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DRUGS
ENZYMES
HYDROXY COMPOUNDS
MEMBRANE PROTEINS
NEUROREGULATORS
NUCLEOTIDYLTRANSFERASES
ORGANIC COMPOUNDS
PHENOLS
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
POLYPHENOLS
PROTEINS
SYMPATHOMIMETICS
TRANSFERASES
550400* - Genetics