Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA cross linking agents
Journal Article
·
· Environ. Mutagen.; (United States)
To see if sodium arsenite enhances the clastogenicity and the mutagenicity of DNA crosslinking agents, Chinese hamster ovary (CHO) cells and human skin fibroblasts were exposed to cis-diamminedichloroplatinum (II) (cis-Pt(II)) or 8-methoxypsoralen (8-MOP) plus long-wave ultraviolet light (UVA) and then to sodium arsenite. The results indicate that the clastogenicity of cis-Pt(II) and 8-MOP pllus UVA are enhanced by the post-treatment with sodium arsenite. Chromatid breaks and exchanges are predominantly increased in doubly treated cells. Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells
- Research Organization:
- Institute of Zoology, Taipei, Taiwan
- OSTI ID:
- 5499021
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 8:1; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
ARSENIC COMPOUNDS
BODY
CHEMICAL REACTIONS
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
COUMARINS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MAN
MUTAGENESIS
MUTATIONS
NEAR ULTRAVIOLET RADIATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PLATINUM COMPOUNDS
POLYMERIZATION
PRIMATES
PSORALEN
RADIATIONS
SKIN
SODIUM COMPOUNDS
SOMATIC CELLS
SYNERGISM
TRANSITION ELEMENT COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
ARSENIC COMPOUNDS
BODY
CHEMICAL REACTIONS
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
COUMARINS
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MAN
MUTAGENESIS
MUTATIONS
NEAR ULTRAVIOLET RADIATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PLATINUM COMPOUNDS
POLYMERIZATION
PRIMATES
PSORALEN
RADIATIONS
SKIN
SODIUM COMPOUNDS
SOMATIC CELLS
SYNERGISM
TRANSITION ELEMENT COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES