Bronchoalveolar permeability changes in rats inhaling gas/particle combinations during rest or exercise
Bronchoalveolar (BA) injury in rats exposed at rest or exercise to air pollutants was studied by changes in epithelial permeability. Rats exposed to air, single gases or pollutant combinations were anesthetized, tracheostomized, and placed on an incline. /sup 99m/Tc-DTPA was delivered directly to a major bronchus. Radioactivity measurements were made on blood samples collected during first 10 min. Exposure of resting rats to 0.6 ppm O/sub 3/ increased BA permeability just after exposure, but it was normal 24 hrs later; in exercising rats the increase was greater than in rats exposed at rest, and it persisted up to 24 hrs. NO/sub 2/ at 6 ppm did not affect permeability. Exposure of resting rats to 2.5 ppm NO/sub 2/ + 0.6 ppm O/sub 3/ only increased permeability right after the exposure, but in exercising rats this exposure resulted in a greater permeability which remained elevated up to 24 hrs. Exposure of exercising rats to 0.8 ppm O/sub 3/ + 10 ppm HCHO increased permeability. Exposure of resting rats to an atmosphere of 0.6 ppm O/sub 3/ + 2.5 ppm NO/sub 2/ + 5 ppm SO/sub 2/ + 1 mg/m/sup 3/ sulfates of ferric, ammonium and manganese also produced an increase in permeability that persisted up to 24 hrs. The results suggest potentiation of the pollutant effects by exercise, but there is no indication of synergistic effect of pollutant combinations on BA permeability.
- Research Organization:
- Univ. of California, Irvine
- OSTI ID:
- 5493340
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALDEHYDES
AMINO ACIDS
AMMONIUM COMPOUNDS
AMMONIUM SULFATES
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHALCOGENIDES
CHELATING AGENTS
DRUGS
DTPA
EPITHELIUM
EXERCISE
FORMALDEHYDE
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
IRON SULFATES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MANGANESE COMPOUNDS
MANGANESE SULFATES
MATERIALS
MORPHOLOGICAL CHANGES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PERMEABILITY
POLLUTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SULFATES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SYNERGISM
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
ULTRASTRUCTURAL CHANGES
YEARS LIVING RADIOISOTOPES