Tracheal and bronchoalveolar permeability changes in rats inhaling oxidant atmospheres during rest or exercise

Journal Article · Wed Dec 31 23:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531083· OSTI ID:5347270

Bhalla, D K; Mannix, R C; Lavan, S M; Phalen, R F; Kleinman, M T; Crocker, T T

Permeability of tracheal and bronchoalveolar airways of rats was measured and used to examine the effects of inhaled oxidant-containing atmospheres. The atmospheres studied were (a) ozone (O/sub 3/) at 0.6 ppm (1.2 mg/m3) or 0.8 ppm (1.6 mg/m3); (b) nitrogen dioxide (NO/sub 2/) at 6 ppm (11.3 mg/m3) or 12 ppm (22.6 mg/m3); (c) O3 + NO/sub 2/ at 0.6 ppm (1.2 mg/m3) and 2.5 ppm (4.7 mg/m3), respectively; and (d) a 7-component particle and gas mixture (complex atmosphere) representing urban air pollution in a photochemical environment. The rats were exposed for 2 h. The effects of exercise during exposure were evaluated by exposing additional groups in an enclosed treadmill. Exposure of resting rats to 0.8 ppm O/sub 3/ increased tracheal permeability to DTPA and bronchoalveolar permeability to diethylenetriamine pentaacetate (DTPA) and bovine serum albumin (BSA) at 1 h after the exposure. Bronchoalveolar, but not tracheal, permeability remained elevated at 24 h after the exposure. Exercise during exposure to O/sub 3/ increased permeability to both tracers in the tracheal and the bronchoalveolar zones, and prolonged the duration of increased permeability in the tracheal zone from 1 h to 24 h, and in the bronchoalveolar zone from 24 h to 48 h. Permeability in the tracheal and bronchoalveolar zones of rats exposed at rest to 6 or 12 ppm NO/sub 2/ did not differ from controls. However, rats exposed during exercise to 12 ppm NO/sub 2/ for 2 h developed a significant increase in tracheal and bronchoalveolar permeability to DTPA and BSA at 1 h, but not at 24 or 48 h, after exposure. Exposure at rest to 0.6 ppm O/sub 3/ plus 2.5 ppm NO/sub 2/ significantly increased bronchoalveolar permeability at 1 and 24 h after exposure, although exposure at rest to 0.6 ppm O/sub 3/ alone increased bronchoalveolar permeability only at 1 h after exposure.

• Research Organization: Univ. of California, Irvine
• OSTI ID: 5347270
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 22:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ALBUMINS
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BRONCHI
CARBOXYLIC ACIDS
CHALCOGENIDES
CHELATING AGENTS
COLLOIDS
DISPERSIONS
DRUGS
DTPA
EXERCISE
INHALATION
INTAKE
MAMMALS
MIXTURES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
OZONE
PERMEABILITY
POLLUTION
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLS
SYNERGISM
TRACHEA
URBAN AREAS
VERTEBRATES