Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985
Technical Report
·
OSTI ID:5222692
The study analyzed rats' nasal, tracheal and bronchoalveolar epithelial permeability to macromolecules after they were exposed, in 2- or 4-hour periods of rest or exercise, to ozone (O/sub 3/)(0.6, 0.8 or 2 ppm), nitrogen dioxide (NO/sub 2/)(2.5, 6 or 12 ppm) or formaldehyde (10 ppm). Exercise was performed on a treadmill operated at a speed that led to a 2-fold increase in oxygen consumption. Histopathologic and electron-microscopic cytochemical and autoradiographic studies were performed to identify the structural aspects of mucosal response. Results indicate that different air pollutants affect different sites in the respiratory tract with respect to epithelial permeability to macromolecules.
- Research Organization:
- Health Effects Inst., Cambridge, MA (USA); California Univ., Irvine (USA)
- OSTI ID:
- 5222692
- Report Number(s):
- PB-86-209855/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
CHALCOGENIDES
FORMALDEHYDE
HAZARDS
HEALTH HAZARDS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
OZONE
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
CHALCOGENIDES
FORMALDEHYDE
HAZARDS
HEALTH HAZARDS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
OZONE
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES