Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985

Technical Report · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5222692

Crocker, T T; Bhalla, D K

The study analyzed rats' nasal, tracheal and bronchoalveolar epithelial permeability to macromolecules after they were exposed, in 2- or 4-hour periods of rest or exercise, to ozone (O/sub 3/)(0.6, 0.8 or 2 ppm), nitrogen dioxide (NO/sub 2/)(2.5, 6 or 12 ppm) or formaldehyde (10 ppm). Exercise was performed on a treadmill operated at a speed that led to a 2-fold increase in oxygen consumption. Histopathologic and electron-microscopic cytochemical and autoradiographic studies were performed to identify the structural aspects of mucosal response. Results indicate that different air pollutants affect different sites in the respiratory tract with respect to epithelial permeability to macromolecules.

• Research Organization: Health Effects Inst., Cambridge, MA (USA); California Univ., Irvine (USA)
• OSTI ID: 5222692
• Report Number(s): PB-86-209855/XAB
• Resource Relation: Other Information: Prepared in cooperation with California Univ., Irvine
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FORMALDEHYDE
BIOLOGICAL EFFECTS
NITROGEN DIOXIDE
OZONE
RESPIRATORY SYSTEM
HEALTH HAZARDS
MICE
RESPIRATION
ALDEHYDES
ANIMALS
CHALCOGENIDES
HAZARDS
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NITROGEN COMPOUNDS
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ORGANIC COMPOUNDS
OXIDES
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RODENTS
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