Monooxygenae induction and chlorobiphenyls in the deep-sea fish Coryphaenoides armatus
Journal Article
·
· Science (Washington, D.C.); (United States)
Inhibition of liver microsomal ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by ..cap alpha..-naphthoflavone and by polyclonal antibodies to hydrocarbon-inducible cytochrome P-450E from teleost liver indicated a xenobiotic-induced origin of these activities in the deep-sea fish Coryphaenoides armatus. Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated zenobiotic-induced cytochrome P-450 in these animals. Levels of apparently induced cytochrome P-450 and monooxygenase activity correlated positively with the tissue content of chlorobiphenyls of known inducing activity, implicating such compounds in biochemical effects occurring in the deep ocean.
- Research Organization:
- Woods Hole Oceanographic Institution, MA
- OSTI ID:
- 5487894
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 231:4743; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHLORINATED AROMATIC HYDROCARBONS
CYTOCHROMES
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
FISHES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
LIVER
METABOLIC ACTIVATION
MICROSOMES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PIGMENTS
PROTEINS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHLORINATED AROMATIC HYDROCARBONS
CYTOCHROMES
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
FISHES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
LIVER
METABOLIC ACTIVATION
MICROSOMES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PIGMENTS
PROTEINS
VERTEBRATES