Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. [Dogs]

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5485281
; ; ; ; ; ; ; ; ;

An in vivo measurement technique using /sup 15/O water and positron CT for quantitation of myocardial blood flow (MBF) was investigated. Oxygen-15 water radioactivity in myocardium was imaged with a NeuroECAT scanner for 10 min, starting at the time of tracer infusion. A separate scan following inhalation of /sup 15/O CO was obtained to label the blood pool and to help remove the contribution of radioactivity in the blood pool during the /sup 15/O water scans. The integrated projection technique was used for calculating MBF. The quantitative microsphere technique for measurement of MBF was performed along with the /sup 15/O water study to provide reference values, with which the MBF values by the in vivo technique were compared. Results of 12 experimental runs (in seven dogs) show the in vivo technique with /sup 15/O water and positron CT can give quantitative flow images of myocardium. The in vivo positron CT measurement was found to correlate well with the in vitro values (by microspheres) over the flow range of 40 to 150 ml/min/100 g.

Research Organization:
Univ. of California, Los Angeles
DOE Contract Number:
AC03-76SF01012
OSTI ID:
5485281
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:6; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

New method for measuring myocardial blood flow by high resolution scintigraphy in the excised dog heart
Journal Article · Wed Oct 01 00:00:00 EDT 1986 · J. Nucl. Med.; (United States) · OSTI ID:6935438
Measurement of absolute myocardial blood flow with H/sub 2//sup 15/O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect
Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Circulation; (United States) · OSTI ID:6908678
Quantification of regional myocardial blood flow in vivo with H/sub 2//sup 15/O. [Dogs]
Journal Article · Mon Oct 01 00:00:00 EDT 1984 · Circulation; (United States) · OSTI ID:5779100

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DATA
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEART
HYDROGEN COMPOUNDS
INFORMATION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
TOMOGRAPHY
USES
VERTEBRATES
WATER