Measurement of absolute myocardial blood flow with H/sub 2//sup 15/O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect
An in vivo technique was developed for measuring the absolute myocardial blood flow with H/sub 2//sup 15/O and dynamic positron-emission tomography. This technique was based on a new model involving the concept of the tissue fraction, which was defined as the fraction of the tissue mass in the volume of the region of interest. The myocardium was imaged dynamically by positron-emission tomography, starting at the time of intravenous bolus injection of H/sub 2//sup 15/O. The arterial input function was measured continuously with a beta-ray detector. A separate image after C/sup 15/O inhalation was also obtained for correction of the H/sub 2//sup 15/O radioactivity in the blood. The absolute myocardial blood flow and the tissue fraction were calculated for 15 subjects with a kinetic technique under region-of-interest analysis. These results seem consistent with their coronary angiographic findings. The mean value of the measured absolute myocardial blood flows in normal subjects was 0.95 +/- 0.09 ml/min/g. This technique detected a diffuse decrease of myocardial blood flow in patients with triple-vessel disease.
- Research Organization:
- Research Institute for Brain and Blood Vessels-AKITA (Japan)
- OSTI ID:
- 6908678
- Journal Information:
- Circulation; (United States), Journal Name: Circulation; (United States) Vol. 78:1; ISSN CIRCA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEART
HYDROGEN COMPOUNDS
IN VIVO
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
TOMOGRAPHY
WATER