Assessment of regional myocardial blood flow and reginal fractional oxygen extraction in dogs, using /sup 15/0-water and /sup 15/0-hemoglobin

Journal Article · Sat Apr 01 04:00:00 EST 1978 · Circ. Res.; (United States)

DOI:https://doi.org/10.1161/01.RES.42.4.511· OSTI ID:5151382

Parker, J A; Beller, G A; Hoop, B; Holman, B L; Smith, T W

A new approach to the assessment of regional myocardial blood flow and fractional oxygen extraction has been developed using /sup 15/0-water (H/sub 2//sup 15/0) and /sup 15/0-hemoglobin (/sup 15/0-Hb). Bolus doses (1mCi) of H/sub 2/-/sup 15/0 and /sup 15/0-H were injected 10 minutes apart into the left main coronary artery of 12 normal dogs. Sequential images of regional myocardial tracer clearance were obtained over 5 minutes with a positron camera. Myocardial blood flow calculated from the monoexponential washout of H/sub 2/-/sup 15/0 after background correction was 78 +/- 6 (SE) m1/100 g per min. Functional images of regional blood flow in which the image of peak activity was divided by the integrated image of H/sub 2/-/sup 15/0 washout were derived by computer processing. These images demonstrated homogeneous blood flow in the normal myocardium. Fractional myocardial 0/sub 2/ extraction was determined from an image of initial distribution of 0/sub 2/ used (obtained after /sup 15/0-Hb administration), divided by initial distribution of 0/sub 2/ delivered (obtained by back extrapolating H/sub 2/-/sup 15/0 washout). These functional images showed uniform distribution of fractional 0/sub 2/ extraction in the normal myocardium. Thus, these studies show that regional myocardial blood flow and regional oxygen extraction can be measured simultaneously by sequential imaging after serial intracoronary injections of H/sub 2/-/sup 15/0 and /sup 15/0-Hb.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 5151382
• Journal Information: Circ. Res.; (United States), Journal Name: Circ. Res.; (United States) Vol. 42:4; ISSN CIRUA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD FLOW
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
EVEN-ODD NUCLEI
GLOBIN
HEART
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
METABOLISM
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PIGMENTS
PORPHYRINS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
REACTION KINETICS
SCINTISCANNING
VERTEBRATES
WATER