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Epidermal I-J-bearing cells are responsible for transferable suppressor cell generation after immunization of mice with ultraviolet radiation-treated epidermal cells

Journal Article · · J. Invest. Dermatol.; (United States)

Subcutaneous immunization of mice with hapten-coupled, ultraviolet radiation (UVR)-treated epidermal cells (EC) results in a hyporesponsive delayed-type hypersensitivity (DTH) response associated with the appearance of afferent-acting, hapten-specific T suppressor (Ts) cells. Depletion of I-J-bearing cells from the EC population prior to UVR-exposure and hapten coupling prevents the appearance of these Ts cells. However, non-UVR-treated EC depleted of I-J-bearing cells and hapten-coupled are capable of immunizing mice for a DTH response. Therefore, the set of I-J-bearing EC appears to be distinct from classic Langerhans cells. A novel set of I-J-bearing EC appears to be responsible for Ts activation after subcutaneous immunization with hapten-coupled UVR-treated EC.

Research Organization:
Harvard Medical School, Boston, MA
OSTI ID:
5480012
Journal Information:
J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 84:3; ISSN JIDEA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
ARSENIC COMPOUNDS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IMMUNOSUPPRESSION
INJECTION
INTAKE
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MICE
ORGANIC ARSENIC COMPOUNDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SUBCUTANEOUS INJECTION
ULTRAVIOLET RADIATION
VERTEBRATES