Epidermal antigen-presenting cells in activation of suppression: identification of a new functional type of ultraviolet radiation-resistant epidermal cell

Journal Article · Tue Jan 31 23:00:00 EST 1984 · J. Immunol.; (United States)

OSTI ID:5004075

Granstein, R D; Lowy, A; Greene, M I

Exposure of mice to low doses of ultraviolet radiation (UVR) in vivo leads to an inability to sensitize them to contact sensitizing reagents at the site of irradiation, and this depressed sensitization is accompanied by the formation of antigen-specific T suppressor (Ts) cells. It has also been demonstrated that hapten-coupled epidermal cells (EC) from UVR-treated mice are unable to immunize mice efficiently when administered subcutaneously, and such immunization results in the appearance of suppressor cells. The authors report that the murine epidermis contains a previously unrecognized antigen-presenting cell (APC) that is required for the activation of suppression, and that this APC is resistant to UVR. The dose of UVR employed is, however, sufficient to prevent substantial positive immunization of mice with syngeneic UV-irradiated hapten-coupled EC. These data explain in part the changes induced in epidermal antigen-presenting function of UVR, and has consequences for the understanding of UVR-induced cutaneous carcinogenesis.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 5004075
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 132:2; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANTIGENS
BODY
CARCINOGENESIS
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
GAMMA RADIATION
IMMUNOLOGY
IMMUNOSUPPRESSION
IONIZING RADIATIONS
MAMMALS
MICE
ORGANS
PATHOGENESIS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES