Impairment of antigen-presenting cell function by ultraviolet radiation

Journal Article · Fri Nov 30 23:00:00 EST 1979 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.76.12.6591· OSTI ID:5369866

Greene, M I ^[1]; Sy, M S; Kripke, M; Benacerraf, B

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1. Harvard Medical School, Boston, MA

uv light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of uv-treated donors could not induce hapten-specific delayed hypersensitivity responses in uv-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cells from normal mice were able to do so. The failure to induce immunity in uv-treated mice by utilizing uv-treated adherent antigen-presenting cells was associated with the development of antigen-specific suppressor T cells. The implication of these results for uv-induced carcinogenesis is discussed.

• OSTI ID: 5369866
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 76:12; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
DYNAMIC FUNCTION STUDIES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
MAMMALS
MICE
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
ULTRAVIOLET RADIATION
VERTEBRATES