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Impairment of antigen-presenting cell function by ultraviolet radiation. II. Effect of in vitro ultraviolet irradiation of antigen-presenting cells

Journal Article · · Transplantation; (United States)
; ; ;

The s.c. injection of 10 mM 2,4,6-trinitrobenzene sulfonic acid (TNBS) derivatized splenic adherent cells (SACs) into syngeneic mice primes for contact sensitivity or delayed-type hypersensitivity (DTH) when these animals are challenged with picryl chloride on the ear or trinitrophenol (TNP)-coupled cells in the footpad, respectively. If recipient mice are exposed to ultraviolet light (UV) irradiation and are immunized with normal TNP-treated SACs, they develop marked DTH reaction upon challenge but develop limited DTH reactions if immunized with hapten-derivatized SACs that had been obtained from UV-treated recipients. Moreover, if the SACs are obtained from normal mice but are treated in vitro with UV light (1.2 to 1.4 mJ/cm/sup 2//sec over the wavelength range 280 to 340 nm at a tube to target distance of 20 cm) these cells can neither prime nor elicit hapten-specific T cell immunity in UV-treated recipients. If UV-treated TNP SACs are used to prime UV-irradiated recipients, TNP-specific suppressor T cells are generated rather than T effector cells.

Research Organization:
Harvard Medical School, Boston, MA
OSTI ID:
6409327
Journal Information:
Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 31:4; ISSN TRPLA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CHEMICAL EXPLOSIVES
ELECTROMAGNETIC RADIATION
EXPLOSIVES
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNITY
IMMUNOLOGY
IMMUNOSUPPRESSION
IN VITRO
INJECTION
INTAKE
MAMMALS
MICE
NITRO COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOLS
PICRIC ACID
RADIATION EFFECTS
RADIATIONS
RADIOIMMUNOLOGY
RADIOSENSITIVITY EFFECTS
RODENTS
SENSITIVITY
SOMATIC CELLS
SPLEEN CELLS
SULFONIC ACIDS
ULTRAVIOLET RADIATION
VERTEBRATES