Technetium-99m HM-PAO-labeled leukocytes in detection of inflammatory lesions: Comparison with gallium-67 citrate

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5477287

Vorne, M; Soini, I; Lantto, T; Paakkinen, S ^[1]

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1. Paeijaet-Haeme Central Hospital, Lahti (Finland)

Forty-three patients with suspected benign, inflammatory, or infectious diseases were imaged with ({sup 99m}Tc)HM-PAO-labeled leukocytes and ({sup 67}Ga)citrate. Technetium-99m leukocytes showed 22 true-positive, no false-positive, 19 true-negative, and two false-negative findings and ({sup 67}Ga)citrate 23, 7, 12 and 1, respectively. The sensitivity, specificity, and accuracy values with {sup 99m}Tc leukocytes were 92%, 100%, and 95%, and with ({sup 67}Ga)citrate 96%, 63%, and 81%. Technetium-99m leukocyte scintigraphy has a promising future in comparison with ({sup 67}Ga)citrate because of the ready availability of ({sup 99m}Tc)HM-PAO, the good image quality, more rapid results (within few hours), and the lower radiation exposure to the patient with {sup 99m}Tc leukocytes. The usefulness of {sup 99m}Tc leukocytes in chronic osteomyelitis needs further evaluation.

• OSTI ID: 5477287
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:8; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
INFECTIOUS DISEASES
DIAGNOSIS
LEUKOCYTES
SCINTISCANNING
RADIOPHARMACEUTICALS
SENSITIVITY ANALYSIS
ACCURACY
CITRATES
COMPARATIVE EVALUATIONS
GALLIUM 67
INFLAMMATION
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
OXIMES
PATIENTS
TECHNETIUM 99
AMINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACID SALTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics