Indium-111-leukocyte/technetium-99m-MDP bone and magnetic resonance imaging: Difficulty of diagnosing osteomyelitis in patients with neuropathic osteoarthropathy

Journal Article · Tue May 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6773991

Seabold, J E; Flickinger, F W; Kao, S C; Gleason, T J; Kahn, D; Nepola, J V; Marsh, J L ^[1]

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1. Univ. of Iowa College of Medicine, Iowa City (USA)

Fourteen patients (16 sites) with clinical and/or radiographic evidence of neuropathic osteoarthropathy (Charcot joints) were evaluated with combined indium-111-leukocyte ({sup 111}In-WBC) and technetium-99m-methylene diphosphonate ({sup 99m}Tc-MDP) bone imaging for suspected osteomyelitis. Magnetic resonance (MR) images were obtained in seven patients. Using a positive bone culture as the criterion for the presence of osteomyelitis, there were four true-positive studies, six true-negative sites, and one false-negative {sup 111}In-WBC study. Five of 16 sites (31%) had false-positive {sup 111}In-WBC uptake at noninfected sites. There were four true-positive and three false-positive MR studies. All false-positives showed at least moderately abnormal findings by both techniques at sites of rapidly progressing osteoarthropathy of recent onset. In this preliminary study, both techniques appear to be sensitive for detection of osteomyelitis, and a negative study makes osteomyelitis unlikely. However, the findings of {sup 111}In-WBC/{sup 99m}Tc-MDP and MR images at sites of rapidly progressing, noninfected neuropathic osteoarthropathy may be indistinguishable from those of osteomyelitis.

• OSTI ID: 6773991
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:5; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
MAMMALS
MAN
MATERIALS
MINUTES LIVING RADIOISOTOPES
NMR IMAGING
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSTEOMYELITIS
PATIENTS
PRIMATES
RADIOISOTOPES
SKELETAL DISEASES
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES