Postoperative bone marrow alterations: Potential pitfalls in the diagnosis of osteomyelitis with In-111-labeled leukocyte scintigraphy

Journal Article · Sun Sep 01 04:00:00 EDT 1991 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.180.3.1871288· OSTI ID:5161751

Seabold, J E; Nepola, J V; Marsh, J L; Hawes, D R; Justin, E P; Ponto, J A; Pettit, W A; el-Khoury, G Y; Kirchner, P T ^[1]

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1. University of Iowa College of Medicine, Iowa City (USA)

Scintigraphy was used after injection of technetium-99m methylene diphosphonate (MDP) and indium-111-labeled white blood cells (WBCs) to assess for the presence of osteomyelitis in 97 patients who had undergone prior surgical procedures. Thirty-four patients with abnormal In-111-labeled WBC patterns underwent restudy with Tc-99m albumin colloid (AC). Scintigraphic findings were considered positive for osteomyelitis whenever localization of In-111-labeled WBCs exceeded Tc-99m AC activity in extent or focal intensity (discordant pattern). Ten of 12 patients with culture-proved osteomyelitis had discordant patterns; two had false-negative (concordant) patterns. The cases of 20 of 22 patients without infection who were considered to have osteomyelitis on the basis of patterns of In-111-labeled WBCs and Tc-99m MDP were reclassified correctly on the basis of concordant patterns of In-111-labeled WBCs and Tc-99m AC. Radiocolloid images improved the overall scintigraphic specificity for osteomyelitis from 59% without bone marrow imaging to 92%; sensitivity decreased from 94% to 88%.

• OSTI ID: 5161751
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 180:3; ISSN RADLA; ISSN 0033-8419
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSTEOMYELITIS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SENSITIVITY ANALYSIS
SKELETAL DISEASES
SPECIFICITY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOI