Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity
Journal Article
·
· Life Sci.; (United States)
Radiothyroidectomy protected against 2,3,7,8-tetrachloro dibenzo-p-dioxin (TCDD)-induced immunotoxicity in rats as assessed by the spleen anti-SRBC plaque-forming cell assay. Thyroxin (T/sub 4/) replacement therapy partially reversed the effects of thyroidectomy on T/sub 4/ and triiodothyronine (T/sub 3/) serum levels, body weight and immune function as well as restored TCDD-induced immunotoxicity. Thus, hypothyroidism induced by TCDD exposure can be viewed as a protective response of the organism to reduce the insult caused by TCDD.
- Research Organization:
- Univ. of Kansas Medical Center, Kansas City
- OSTI ID:
- 5475335
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 36:7; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a complex environmental mixture from the Love Canal
Enhanced suppressor cell activity as a mechanism of immunosuppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Journal Article
·
Tue Jan 31 23:00:00 EST 1989
· Fundam. Appl. Toxicol.; (United States)
·
OSTI ID:6021112
Enhanced suppressor cell activity as a mechanism of immunosuppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Journal Article
·
Sat Oct 31 23:00:00 EST 1981
· Proc. Soc. Exp. Biol. Med.; (United States)
·
OSTI ID:5543478
Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Journal Article
·
Sat Dec 31 23:00:00 EST 1988
· American Journal of Industrial Medicine; (USA)
·
OSTI ID:5477854
Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
DIOXIN
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYPOTHYROIDISM
IMMUNE REACTIONS
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SURGERY
THERAPY
THYROID
THYROID HORMONES
THYROIDECTOMY
THYROXINE
TOXICITY
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
DIOXIN
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYPOTHYROIDISM
IMMUNE REACTIONS
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SURGERY
THERAPY
THYROID
THYROID HORMONES
THYROIDECTOMY
THYROXINE
TOXICITY
VERTEBRATES