Enhanced suppressor cell activity as a mechanism of immunosuppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Journal Article · Sun Nov 01 04:00:00 EST 1981 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-168-41275· OSTI ID:5543478

Clark, D A; Gauldie, J; Szewczuk, M R; Sweeney, G

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), a toxic halogenated aromatic hydrocarbon, acts in the body as a cumulative poison. The chronic immunotoxic effects of TCDD were studied in C57B1/6 male mice. Total doses of 100 ..mu..g/kg or greater produced cellular depletion in thymus, spleen, and lymph nodes, and the animals appeared sick. No cellular depletion was seen following 0.4 ..mu..g/kg, and only thymus was affected by 4 and 40 ..mu..g/kg. The antibody response to SRBC and TNP-Brucella abortus was impaired following ..mu..g/kg and the generation of alloantigen-specific cytotoxic T cells (CTL) was sensitive to as little as 0.004 ..mu..g/kg TCDD. In vitro analysis of the mechanism of suppression using limiting dilution techniques showed that TCDD did not deplete the precursors of CTL but generated cells capable of suppressing CTL generation in vitro.

• Research Organization: McMaster Univ., Hamilton, Ontario, Canada
• OSTI ID: 5543478
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 168:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
AROMATICS
BIOLOGICAL EFFECTS
BODY
DATA
DIOXIN
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
IMMUNOSUPPRESSION
IN VITRO
INFORMATION
INJURIES
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MICE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RODENTS
SPLEEN
THYMUS
TOXICITY
VERTEBRATES