Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Journal Article · Sun Jan 01 04:00:00 EST 1989 · American Journal of Industrial Medicine; (USA)

DOI:https://doi.org/10.1002/ajim.4700160205· OSTI ID:5477854

Patterson, Jr, D G; Fingerhut, M A; Roberts, D W; Needham, L L; Sweeney, M H; Marlow, D A; Andrews, Jr, J S; Halperin, W E ^[1]

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1. Department of Health and Human Services, Atlanta, GA (USA)

Review of employment and chemical production records at a Missouri chemical plant and of questionnaires with self-reported occupational exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin (2,3,7,8-TCDD) for 16 Missouri workers has explained the wide diversity of 2,3,7,8-TCDD levels previously reported in the workers' adipose tissue (3.5-750 ppt on whole-weight basis). We show that the highest exposures reported to date in the United States occurred in a group of nine production workers who made products contaminated with 2,3,7,8-TCDD. The nine workers had adipose tissue levels with a mean of 246 ppt and a range of 42 to 750 ppt. Seven persons who worked at the same chemical company, but not in the 2,3,7,8-TCDD-contaminated process, had a mean of 8.7 ppt and a range of 3.5 to 25.8 ppt. We also report serum levels of 2,3,7,8-TCDD in these individuals. The adipose tissue from a subset of four production workers with elevated levels of 2,3,7,8-TCDD and seven Missouri residents with normal 2,3,7,8-TCDD levels was also analyzed for other isomers of the PCDDs and PCDFs. The mean adipose tissue level of 2,3,7,8-TCDD in the subset of production workers was 45 times higher than the mean level in the unexposed Missouri residents, but similar levels of the other PCDDs and PCDFs were found in both groups.

• OSTI ID: 5477854
• Journal Information: American Journal of Industrial Medicine; (USA), Journal Name: American Journal of Industrial Medicine; (USA) Vol. 16:2; ISSN 0271-3586; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
BIOLOGICAL ACCUMULATION
BODY
CHEMICAL INDUSTRY
CONNECTIVE TISSUE
DIOXIN
FEDERAL REGION VII
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
INDUSTRY
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MAN
MISSOURI
NORTH AMERICA
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PERSONNEL
PRIMATES
TISSUES
USA
VERTEBRATES