Metabolic disposition of 14C-metanil yellow in guinea pigs

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Veterinary and Human Toxicology; (United States)

OSTI ID:5462590

Singh, R L; Khana, S K; Singh, G B ^[1]

---

1. Department of Biochemistry, College of Basic Sciences and Humanities GB Pant University of Agriculture and Technology, Pantnagar (India)

The absorption, metabolism and excretion of 14C-metanil yellow was studied in guinea pigs. Following administration of a single po dose of 5 mg dye (7.6 mu Ci)/kg body weight, 83.4% was excreted through urine and feces within 96 h with the majority accounted for in feces. Liver, kidney and spleen did not have marked accumulation of counts, whereas testes and gastrointestinal tract retained 1.9 and 9.7% of the radioactivity, respectively. Analysis of urine and feces detected 2 azo-reduction metabolites of metanil yellow which were characterized by TLC and IR, NMR and mass spectroscopic studies as metanilic acid and p-aminodiphenylamine.

• OSTI ID: 5462590
• Journal Information: Veterinary and Human Toxicology; (United States), Journal Name: Veterinary and Human Toxicology; (United States) Vol. 33:3; ISSN 0145-6296; ISSN VHTOD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZO COMPOUNDS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CHROMATOGRAPHY
CLEARANCE
DYES
EXCRETION
FECES
GUINEA PIGS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MASS SPECTROSCOPY
MATERIALS
METABOLISM
METABOLITES
NMR SPECTRA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
SEPARATION PROCESSES
SPECTRA
SPECTROSCOPY
THIN-LAYER CHROMATOGRAPHY
TRACER TECHNIQUES
VERTEBRATES
WASTES