Disposition of 2-mercaptobenzothiazole and 2-mercaptobenzothiazole disulfide in rats dosed intravenously, orally, and topically and in guinea pigs dosed topically

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Journal of Toxicology and Environmental Health; (USA)

DOI:https://doi.org/10.1080/15287398909531279· OSTI ID:5404442

el Dareer, S M; Kalin, J R; Tillery, K F; Hill, D L; Barnett, Jr, J W ^[1]

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1. Southern Research Institute, Birmingham, AL (USA)

To determine the metabolic disposition of (14C)-2-mercaptobenzothiazole (MBT) and (14C)-2-mercaptobenzothiazole disulfide (MBTS), male and female rats were dosed topically. Topical doses were 36.1 micrograms/animal for (14C)MBT and 33.6 micrograms/animal for (14C)MBTS. Although more MBT passed through the skin than MBTS and although, relative to rats, guinea pigs absorbed a greater percentage of the dose (33.4% compared to 16.1-17.5% of the MBT and 12.2% compared to 5.94-7.87% for MBTS), the disposition of radioactivity derived from the two compounds was similar. Washing of the skin removed more of the radioactivity from guinea pigs than from rats. For both sexes of rats dosed intravenously with (14C)MBT or (14C)MBTS, disposition of the compounds was similar. In 72 h, 90.9-101% of the dose appeared in the urine and 3.79-15.1% in the feces. At this time, a small portion of the administered radioactivity remained associated with erythrocytes. Oral dosing of rats for 14 d with unlabeled MBT prior to a single dose of (14C)MBT or with unlabeled MBTS prior to a single dose of (14C)MBTS (0.730 mg/kg). For both sexes, disposition of the compounds was similar. At 96 h after dosing, a small portion of the administered radioactivity remained associated with erythrocytes, most of which was bound to the membranes. For both compounds and sexes, 60.8-101% of the radioactivity administered appeared in the urine and 3.46-9.99% in the feces in 96 h. At the time, only trace amounts of radioactivity remained in tissues other than blood. Of these tissues, thyroid contained the highest concentration. In the urine, there was a detectable MBT or MBTS, but there were two metabolites, one of which was identified as a thioglucuronide derivative of MBT. The other was possibly a sulfonic acid derivative of MBT.

• OSTI ID: 5404442
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Vol. 27:1; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
THIAZOLES
METABOLISM
CARBON 14 COMPOUNDS
ENVIRONMENTAL EXPOSURE
GUINEA PIGS
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
ORAL ADMINISTRATION
RATS
SKIN ABSORPTION
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ABSORPTION
ANIMALS
AZOLES
DISTRIBUTION
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
UPTAKE
VERTEBRATES
550501* - Metabolism- Tracer Techniques