Interaction of electromagnetic fields with biosynthetic processes in connective-tissue cells. Final report, 31 Mar 89-30 Apr 90

Technical Report · Fri Dec 01 04:00:00 EST 1989

OSTI ID:5457311

Grodzinsky, A J; Buschmann, M D; Gluzband, Y A

The specific objectives of this research period were: (1) determine whether chondrocytes can be maintained in long-term (2-3 months) culture in agarose gel in order to test the effects of chronic as well as acute response to exposure to electromagnetic fields; (2) measure chondrocyte proliferation, biosynthetic rates for proteoglycans and proteins, total accumulation of proteoglycans, and physical properties of agarose/chondrocyte gel cultures; (3) construct specialized chambers for application of electric fields to agarose/chondrocyte disks in a standard incubator environment; and (4) begin experiments to measure the effects of applied current densities over a wide range of amplitudes and frequencies on biosynthesis of proteoglycans and proteins.

• Research Organization: Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Electrical Engineering and Computer Science
• OSTI ID: 5457311
• Report Number(s): AD-A-234221/0/XAB; CNN: F33615-87-D-0609
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARTILAGE
CONNECTIVE TISSUE
DENSITY
ELECTROMAGNETIC FIELDS
ORGANIC COMPOUNDS
PHYSICAL PROPERTIES
PROTEINS
SENSITIVITY
SYNTHESIS
TISSUES