Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5456361

Loennerdal, B; Keen, C L; Bell, J G; Golub, M; Gershwin, M E; Hurley, L s; Hendrickx, A G

One compensatory mechanism for marginal Zn intake may be enhanced absorption of Zn. While there is some experimental evidence to support this hypothesis from rodent models, there are few data from higher mammalian species. Such a compensatory mechanism of enhanced Zn absorption could be of value to the neonate, as poor Zn nutriture during early life has severe consequences on growth and development. The authors have investigated the absorption of Zn by infant Rhesus monkeys born to control and Zn-restricted mothers. Fasted infant monkeys (100 d) from mothers fed a 100 or 4 ppm Zn diet were intubated with an infant formula containing Zn-65. Whole body radioactivity was counted immediately after intubation and on days 10 and 17 post-intubation. Day 10 data were used to calculate apparent absorption values. Regardless of dietary group, apparent Zn absorption as high, ranging from 30-60% of the dose fed. While there was not a marked difference between the two groups in the groups in the dose absorbed, an inverse correlation was noted between infant body weight and Zn absorption. An inverse correlation was found for plasma Zn concentration and apparent Zn absorption. These results suggest that body weight and plasma Zn level, as related to Zn status and growth rate, may be predictors of Zn absorption.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5456361
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMAL GROWTH
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GROWTH
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
MONKEYS
NEONATES
NUCLEI
PRIMATES
RADIOISOTOPES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
WEIGHT
ZINC
ZINC 65
ZINC ISOTOPES