Effect of low zinc formula on zinc status, zinc absorption and immune function in rhesus monkeys
- Univ. of California, Davis (United States)
Low Zn intake causes decreased growth and impaired immune function during infancy. However, little is known about the events causing these outcomes and the body's capacity to adapt to a low intake. To study this, 3 groups of infant rhesus monkeys were fed from birth to 5 mo of age either a regular infant formula or a low Zn formula. Since the Fe level of formula may affect Zn absorption, the low Zn formula was given without or with Fe supplement. At monthly intervals, Zn absorption was assessed by gavage feeding with {sup 65}Zn and whole body counting immediately after and at 4 to 7 days post-dosing. Before each dosing, blood samples were drawn and hemoglobin, ferritin, cytokines, plasma Zn and Cu, and metallothionein (Mt) were determined. Infants fed low Zn formula had slower weight gain than controls; however, plasma Zn levels were normal. Plasma Mt levels were lower in low Zn infants at 1 mo, but normalized thereafter. Zn retention was higher in both low Zn groups than in controls. Hemoglobin levels were normal in all groups and Fe intake did not affect Zn absorption or status. Neutrophil chemotaxis assessed at the end of the study was impaired in low Zn infants as compared to controls. In conclusion, low Zn intake causes up-regulation of Zn absorption but not enough to fully compensate for the lower Zn intake.
- OSTI ID:
- 5146541
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of marginal maternal zinc intake on zinc absorption and growth of 3-month-old infant rhesus monkeys
Influence of dietary zinc intake on pregnancy outcome in rhesus monkeys
Related Subjects
METALLOTHIONEIN
BIOSYNTHESIS
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
ZINC
BIOLOGICAL EFFECTS
ANIMAL GROWTH
HEMOGLOBIN
INTAKE
INTERFERON
INTESTINAL ABSORPTION
METABOLISM
MONKEYS
NEONATES
TRACER TECHNIQUES
ZINC 65
ABSORPTION
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLOBINS
GROWTH
GROWTH FACTORS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LYMPHOKINES
MAMMALS
METALLOPROTEINS
METALS
MITOGENS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
RADIOISOTOPES
SYNTHESIS
TISSUES
UPTAKE
VERTEBRATES
ZINC ISOTOPES
560300* - Chemicals Metabolism & Toxicology