Effect of low zinc formula on zinc status, zinc absorption and immune function in rhesus monkeys

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5146541

Loennerdal, B; Polberger, S; Vruwink, K; Fletcher, M; Gershwin, M E ^[1]

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1. Univ. of California, Davis (United States)

Low Zn intake causes decreased growth and impaired immune function during infancy. However, little is known about the events causing these outcomes and the body's capacity to adapt to a low intake. To study this, 3 groups of infant rhesus monkeys were fed from birth to 5 mo of age either a regular infant formula or a low Zn formula. Since the Fe level of formula may affect Zn absorption, the low Zn formula was given without or with Fe supplement. At monthly intervals, Zn absorption was assessed by gavage feeding with {sup 65}Zn and whole body counting immediately after and at 4 to 7 days post-dosing. Before each dosing, blood samples were drawn and hemoglobin, ferritin, cytokines, plasma Zn and Cu, and metallothionein (Mt) were determined. Infants fed low Zn formula had slower weight gain than controls; however, plasma Zn levels were normal. Plasma Mt levels were lower in low Zn infants at 1 mo, but normalized thereafter. Zn retention was higher in both low Zn groups than in controls. Hemoglobin levels were normal in all groups and Fe intake did not affect Zn absorption or status. Neutrophil chemotaxis assessed at the end of the study was impaired in low Zn infants as compared to controls. In conclusion, low Zn intake causes up-regulation of Zn absorption but not enough to fully compensate for the lower Zn intake.

• OSTI ID: 5146541
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMAL GROWTH
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLOBINS
GROWTH
GROWTH FACTORS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTAKE
INTERFERON
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
LYMPHOKINES
MAMMALS
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
MITOGENS
MONKEYS
NEONATES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
RADIOISOTOPES
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
SYNTHESIS
TISSUES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES