Interaction of ionizing radiation, genetically active chemicals, and radiofrequency radiation in human and rodent cells. Final report 1 Oct 87-30 Sep 89
The purpose of this project was to investigate the possible interaction between radiofrequency radiation (RFR) and agents which are known to damage DNA. Experiments were performed using exposures of CHO cells to 350, 850, 1200, and 2450 MHz RFR at up to 40 W/kg and temperatures ranging from 37 to 40 C. No genotoxic effect was observed by sister chromotid exchange induction, chromosome aberration induction, or gene mutation (at the thymidine kinase locus). At levels at or below 10 mW/cm2 and specific absorption rates (SARs) at or below 4 W/kg, there was no evidence that DNA repair was induced or repair of preexisting DNA damage was inhibited. Adriamycin but not mitomycin c caused a statistically significant increase in the frequency of aberrant cells at 40 C with or without RFR. These observations support thermal mechanisms of RFR interaction.
- Research Organization:
- Texas Univ., San Antonio, TX (United States). Health Science Center
- OSTI ID:
- 5448754
- Report Number(s):
- AD-A-234747/4/XAB; CNN: F33615-87-C-0610
- Country of Publication:
- United States
- Language:
- English
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Cells
& Tissue Culture
560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHO CELLS
CHROMOSOMAL ABERRATIONS
DNA REPAIR
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
GENE MUTATIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IONIZING RADIATIONS
MAMMALS
MAN
MITOMYCIN
MUTAGENS
MUTATIONS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOWAVE RADIATION
RECOVERY
REPAIR
RODENTS
SISTER CHROMATID EXCHANGES
VERTEBRATES