Biophysical techniques for examining metabolic, proliferative, and genetic effects of microwave radiation. Final report, 1 Oct 89-30 Aug 90
Technical Report
·
OSTI ID:6140585
This project was undertaken to prepare for a comprehensive research effort examining metabolic, proliferative, and genetic effects of microwave radiation. To accomplish this task, preliminary studies have been performed with 4 cells systems; Chinese hamster ovary (CHO) cells, AS52 Chinese hamster cells (heterozygous at the xanthine-guanine phosphoribosyl transferase (XGPRT) locus), 244B proliferating human lymphoblastoid cells, and freshly isolated peripheral lymphocytes. The thermal response of the 244B cells has been carefully examined, and an initial characterization of the membrane markers, membrane permeability, and cell cycle distribution of these cells undertaken. The absence of the induction of chromosome aberrations in CHO cells, after exposure to 850 MHz pulsed wave (PW), 18mW/cm2 (specific absorption rate (SAR) 14.4 W/kg) radiofrequency radiation (RFR), or after exposure to 1,200 MHz PW (220 W -300 W) net forward power; SAR 24.33 W/kg RFR, is reported. The survival response of the AS52 cells, after simultaneous treatment at 37 C or 40 C, with and without mitomycin or adriamycin, is described. The survival of the AS52 cells after X-ray exposure at low and high dose rates is also described.
- Research Organization:
- Georgia Inst. of Tech., Atlanta, GA (United States). Research Inst.
- OSTI ID:
- 6140585
- Report Number(s):
- AD-A-241903/4/XAB; CNN: F33615-87-D-0626
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CONSTITUENTS
CELL CYCLE
CELL MEMBRANES
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GONADS
HAMSTERS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANES
METABOLISM
MICROWAVE RADIATION
MUTATIONS
ORGANS
OVARIES
PERMEABILITY
PRIMATES
RADIATIONS
RODENTS
SENSITIVITY
SOMATIC CELLS
VERTEBRATES
X RADIATION
Cells
& Tissue Culture
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CONSTITUENTS
CELL CYCLE
CELL MEMBRANES
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GONADS
HAMSTERS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANES
METABOLISM
MICROWAVE RADIATION
MUTATIONS
ORGANS
OVARIES
PERMEABILITY
PRIMATES
RADIATIONS
RODENTS
SENSITIVITY
SOMATIC CELLS
VERTEBRATES
X RADIATION