Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
C3H/10T 1/2 cells were infected with a retroviral vector expressing a mouse c-myc oncogene and a drug-selection marker. The resulting cells, morphologically indistinguishable from C3H/10T l/1, displayed a greatly enhanced sensitivity to neoplastic transformation by ionizing radiation or by a chemical carcinogen. Constitutive expression of myc therefore appears to synergize with an initial carcinogenic event, providing a function analogous to a subsequent event that apparently is required for the neoplastic transformation of these cells. This cell system should prove useful in exploring early stages in radiation-induced transformation.
- Research Organization:
- Cornell Univ. Graduate School of Medical Sciences, New York, NY
- OSTI ID:
- 5441715
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:12; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Thesis/Dissertation
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Thu Dec 31 23:00:00 EST 1987
·
OSTI ID:6148613
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· Proceedings of the National Academy of Sciences of the United States of America; (USA)
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CELL TRANSFORMATIONS
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELECTROPHORESIS
FIBROBLASTS
GAMMA RADIATION
GENES
HYBRIDIZATION
IONIZING RADIATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ONCOGENES
ONCOGENIC TRANSFORMATIONS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CELL TRANSFORMATIONS
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELECTROPHORESIS
FIBROBLASTS
GAMMA RADIATION
GENES
HYBRIDIZATION
IONIZING RADIATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ONCOGENES
ONCOGENIC TRANSFORMATIONS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES