Neoplastic transformation and tumorigenesis by the human protooncogene MYC

Journal Article · Thu Mar 01 04:00:00 EST 1990 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.87.6.2102· OSTI ID:6171138

Ramsay, G M; Bishop, J M ^[1]; Moscovici, G; Moscovici, C ^[2]

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1. Univ. of California, San Francisco (USA)
2. Univ. of Florida, Gainesville (USA)

Damage to the protooncogene MYC has been implicated in the genesis of diverse human tumors, but the tumorigenic potential of the isolated gene has been disputed. Here the authors report the use of a retroviral vector to test the potency of human MYC for neoplastic transformation in avian cells. They found that sustained and abundant expression of MYC can transform both embryonic fibroblasts and hematopoietic cells and elicit granulocytic leukemias in chickens. Transformation by MYC is accompanied by changes in diverse aspects of cellular phenotype, including morphology, ability to grow in suspension, rate of proliferation, the structure of the cytoskeleton, and the composition of the extracellular matrix. Nevertheless, the biological potency of MYC is inherently constrained when compared to that of the retroviral oncogene v-myc. The findings enlarge on previous descriptions of neoplastic transformation by MYC and sustain the view that ungoverned expression of the gene can contribute to the genesis of human tumors.

• OSTI ID: 6171138
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 87:6; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIRDS
CARBOXYLIC ACIDS
CARCINOGENESIS
CELL CULTURES
CELL TRANSFORMATIONS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
EVEN-ODD NUCLEI
FIBROBLASTS
GENE REGULATION
GENES
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
ISOTOPES
LEUKEMIA
LIGHT NUCLEI
LIPOTROPIC FACTORS
MAMMALS
MAN
METHIONINE
MICROORGANISMS
MORPHOLOGICAL CHANGES
NEOPLASMS
NUCLEI
ONCOGENES
ONCOGENIC TRANSFORMATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARASITES
PATHOGENESIS
PRIMATES
RADIOISOTOPES
SOMATIC CELLS
STEM CELLS
SULFUR 35
SULFUR ISOTOPES
TUMOR CELLS
VERTEBRATES
VIRUSES