Effect of chronic aspirin ingestion on epithelial proliferation in rat fundus, antrum, and duodenum

Journal Article · Mon May 01 00:00:00 EDT 1972 · Gastroenterology; (United States)

OSTI ID:5441253

Eastwood, G L; Quimby, G F

We studied the effect of chronic aspirin ingestion on gastroduodenal epithelial proliferation by feeding rats aspirin in the drinking water. A control group of rats received plain water. At the end of 4 wk, (3H)-thymidine was given intravenously to label proliferating cells, and the rats were killed 1 h later. Sections of fundus, antrum, and proximal duodenum were processed for light autoradiography. We found that chronic aspirin ingestion stimulated epithelial proliferation in fundic mucosa but had no effect in the antrum. In the duodenum, aspirin increased proliferation in the lowest four crypt-cell positions, which most likely indicates an increase in stem-cell production. None of the tissues contained evidence of inflammation or ulceration. The proliferative effects of aspirin may help explain the previously observed phenomenon of mucosal adaptation in the rat after repeated exposure to aspirin. Further, if human gastroduodenal epithelium responds in a similar manner to chronic aspirin exposure, the effects on proliferation may explain in part the distribution of aspirin-associated ulcers.

• Research Organization: Department of Medicine, University of Massachusetts Medical School, Worcester
• OSTI ID: 5441253
• Journal Information: Gastroenterology; (United States), Vol. 82:5 Pt 1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACETYLSALICYLIC ACID
BIOLOGICAL EFFECTS
EPITHELIUM
CELL PROLIFERATION
INGESTION
RATS
ANALGESICS
ANIMAL TISSUES
ANIMALS
ANTIPYRETICS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HYDROXY ACIDS
INTAKE
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
TISSUES
VERTEBRATES
550901* - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques