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Epithelial cell proliferation in human fundic and antral mucosae. Influence of superselective vagotomy and relationship with gastritis

Journal Article · · Dig. Dis. Sci.; (United States)
DOI:https://doi.org/10.1007/BF01315600· OSTI ID:6294173
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Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se.

Research Organization:
INSERM U.10, Paris, France
OSTI ID:
6294173
Journal Information:
Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 11; ISSN DDSCD
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
AUTONOMIC NERVOUS SYSTEM
AUTORADIOGRAPHY
AZINES
BODY
CELL PROLIFERATION
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
EPITHELIUM
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
INFLAMMATION
LABELLED COMPOUNDS
MEDICINE
MEMBRANES
MUCOUS MEMBRANES
NERVES
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PYRIMIDINES
RIBOSIDES
STOMACH
SURGERY
SYMPTOMS
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
ULCERS
VAGUS