Effect of misoprostol and cimetidine on gastric cell labeling index
The effect of misoprostol and cimetidine on gastric cell turnover was studied. Endoscopic biopsy specimens of fundic and antral mucosa were obtained from duodenal ulcer patients before and after 4 wk of therapy with cimetidine 1.2 g/day or misoprostol 800 micrograms/day. Biopsy specimens were incubated with (/sup 3/H)thymidine. Glandular column length and number of labeled cells were determined after autoradiography. There was no significant difference in column length of antral or fundic glands before or after therapy with cimetidine and misoprostol. The number of antral and fundic labeled cells was significantly decreased after misoprostol treatment (3.6 +/- 0.3 and 4.6 +/- 0.4, mean +/- SE), as opposed to their respective number before therapy (6.9 +/- 0.5 and 8.3 +/- 0.8) (p less than 0.01). On the other hand, after treatment with cimetidine, the number of antral and fundic labeled cells was significantly higher (11.8 +/- 0.9 and 7.5 +/- 1.0, respectively) as compared with their number before therapy (5.7 +/- 0.5 and 5.6 +/- 0.6, respectively). The decreased gastric cell turnover induced by misoprostol indicates that the trophic effect of prostanoids on gastric mucosa is not due to an increase in cellular kinetics. The increased gastric cell turnover induced by cimetidine may contribute to its therapeutic effect in peptic ulcer disease.
- Research Organization:
- Hadassah Univ. Hospital Jerusalem, Israel
- OSTI ID:
- 5218385
- Journal Information:
- Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 1; ISSN GASTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BIOPSY
BODY
CARBONIC ACID DERIVATIVES
CELL DIVISION
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
EPITHELIUM
GASTROINTESTINAL TRACT
GUANIDINES
HETEROCYCLIC COMPOUNDS
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MEMBRANES
MUCOUS MEMBRANES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PROSTAGLANDINS
PYRIMIDINES
RIBOSIDES
SMALL INTESTINE
THERAPY
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULCERS