Harman inhibits the removal of pyrimidine dimers from the DNA of human cells

Journal Article · Thu Feb 12 04:00:00 EST 1981 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(81)91185-2· OSTI ID:5440726

Castellani, A; Setlow, R B

Normal human fibroblasts were UV-irradiated and incubated for 6 hr with harman. The losses of sites, in the extracted DNA, sensitive to a UV specific endonuclease were determined as precision measures of the excision of UV-induced pyrimidine dimers. Harman inhibited excision, rising from approx. 30% inhibition at 200 ..mu..M to 75% inhibition at 500 ..mu..M.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 5440726
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 98:3; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZINES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONNECTIVE TISSUE CELLS
DIMERS
DNA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FIBROBLASTS
HETEROCYCLIC COMPOUNDS
INDOLES
INHIBITION
IRRADIATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
PYRROLES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SOMATIC CELLS
ULTRAVIOLET RADIATION