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Recombination of uv-induced pyrimidine dimers in human fibroblasts

Journal Article · · Biochem. Biophys. Res. Commun.; (United States)
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The appearance of UV-endonuclease-sensitive sites in DNA synthesized after UV irradiation has been monitored in human fibroblasts. The data indicate that 5 percent of the sites originally induced can be found in this DNA. Such sites are found in both normal excision-proficient fibroblasts and in those from xeroderma pigmentosum patients lacking the ability to excise UV-induced pyrimidine dimers.

Research Organization:
Oak Ridge National Lab., TN
OSTI ID:
7122281
Journal Information:
Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 72:3; ISSN BBRCA
Country of Publication:
United States
Language:
English

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