X-ray-induced chromosome aberrations in Down lymphocytes: an explanation of their increased sensitivity

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860030109· OSTI ID:5440721

Preston, R J

Unstimulated lymphocytes from individuals with Down Syndrome (trisomy 21) are more sensitive to the induction of dicentric and ring aberrations by X rays than normal lymphocytes. Several explanations involving the more rapid rejoining of X-ray-induced lesions in Down cells have been offered. It is shown here that the repair of the DNA damage converted into chromosome aberrations is more rapid in Down cells than normal cells. This more rapid repair results in a higher probability of producing chromosome aberrations, and hence higher aberration frequencies in Down than normal cells.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5440721
• Journal Information: Environ. Mutagen.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
DNA
BIOLOGICAL REPAIR
LYMPHOCYTES
RADIOSENSITIVITY
DOWNS SYNDROME
X RADIATION
ANIMAL CELLS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HEREDITARY DISEASES
IONIZING RADIATIONS
LEUKOCYTES
MALFORMATIONS
MATERIALS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RADIATIONS
RECOVERY
REPAIR
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)